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Knowledge Base

Our Published papers

Imaging with the Super-resolution Microsphere Amplifying Lens (SMAL) Nanoscope
"The basic principle of the SMAL (Super-resolution Microsphere Amplifying Lens) imaging technology that we invented has its roots in the SMON (Submerged Microsphere Optical Nanoscope) pioneering work. SMAL is a novel objective lens whose front lens assembly contains a microsphere and is replaceable. We built a nanoscope prototype with nano XYZ scanning capability, which integrates a SMAL objective lens, allowing us to achieve super resolution imaging (70 nm – 90 nm). We have resolved large area scans (200 µm x 200 µm) by contactless sample scanning."
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May 3, 2018
JOURNAL OF PHYSICS: CONFERENCE SERIES
Optical Tweezers Microsphere-lens Super-Resolution Imaging System
"We have demonstrated a novel, non-contacting super-resolution imaging setup using optical tweezers designed in-house. We resolve large area of samples using laser-trapped polystyrene microsphere scanning with resolution below the diffraction limit."
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April 2, 2017
OPTICAL SOCIETY OF AMERICA
Optical Scanning Nanoscope with Microsphere Attached Objective Lens for Super Resolution 3D Virtual Imaging
"We have demonstrated an objective lens attachment comprising a single microsphere lens for achieving super resolution virtual imaging. We have resolved large areas with resolutions below the diffraction limit through contactless sample scanning."
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April 2, 2017
OPTICAL SOCIETY OF AMERICA
Label-free Super-resolution Imaging of Adenoviruses by Submerged Microsphere Optical Nanoscopy
Because of the small sizes of most viruses (typically 5–150nm), standard optical microscopes, which have an optical diffraction limit of 200nm, are not generally suitable for their direct observation. Electron microscopes usually require specimens to be placed under vacuum conditions, thus making them unsuitable for imaging live biological specimens in liquid environments. Indirect optical imaging of viruses has been made possible by the use of fluorescence optical microscopy that relies on the stimulated emission of light from the fluorescing specimens when they are excited with light of a specific wavelength, a process known as labeling or self-fluorescent emissions from certain organic materials. In this paper, we describe direct white-light optical imaging of 75-nm adenoviruses by submerged microsphere optical nanoscopy (SMON) without the use of fluorescent labeling or staining. The mechanism involved in the imaging is presented. Theoretical calculations of the imaging planes and the magnification factors have been verified by experimental results, with good agreement between theory and experiment."
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September 27, 2013
LIGHT SCIENCE & APPLICATIONS
Optical Virtual Imaging at 50 nm Lateral Resolution With a White-light Nanoscope
The imaging resolution of a conventional optical microscope is limited by diffraction to ∼200 nm in the visible spectrum. Efforts to overcome such limits have stimulated the development of optical nanoscopes using metamaterial superlenses, nanoscale solid immersion lenses and molecular fluorescence microscopy. "These techniques either require an illuminating laser beam to resolve to 70 nm in the visible spectrum or have limited imaging resolution above 100 nm for a white-light source. Here we report a new 50-nm-resolution nanoscope that uses optically transparent microspheres (for example, SiO2, with 2 μm<diameter<9 μm) as far-field superlenses (FSL) to overcome the white-light diffraction limit. The microsphere nanoscope operates in both transmission and reflection modes, and generates magnified virtual images with a magnification up to ×8. It may provide new opportunities to image viruses and biomolecules in real time."
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March 1, 2011
NATURE COMMUNICATIONS